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Henry Hallett Dale was born in Islington, London, to Charles James Dale, a pottery manufacturer from Staffordshire, and his wife, Frances Anne Hallett, daughter of a furniture manufacturer. Henry was the third of seven children, one of whom (his younger brother, Benjamin Dale) became an accomplished composer and warden of the Royal Academy of Music. ...
Dale (MRC National Institute for Medical Research) won the 1936 Nobel Prize in Physiology or Medicine for his findings about how nerves use chemicals to transmit messages to each other. When two nerves cells meet end-to-end, there is a gap between them called a synapse. Chemical transmitters, released from the end of one nerve, flow across this gap to the ...
Sir Henry's researches have involved a painstaking investigation of the pharmacology of ergot alkaloids and a study of the effects of incidental bases of a simpler nature, such as tyramine and histamine. He discovered the oxytocic action of pituitary extracts, and his continued work on the action of histamine led to studies on anaphylaxis and on conditions of shock. He ...
Although Dale and his colleagues first identified acetylcholine in 1914 as a possible neurotransmitter, Loewi showed its importance in the nervous system. The two men shared the 1936 Nobel Prize for Medicine ...
After receiving his bachelor’s degree (1903) from the University of Cambridge, Dale began his research career in 1904 at the Wellcome Physiological Research Laboratories. In 1909 he completed his medical degree (M.D.) at Cambridge and in 1914 joined the staff of what later became the Medical Research Council. From 1928 to 1942 he was director of its subsidiary organization, the ...
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