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Reported Question / Answer
Q.) The primary defect which leads to sickle cell anemia is
1)
Replacement of glutamate by valine in beta-chain of HbA
2)
An abnormality in porphyrin part of hemoglobin
3)
Substitution of valine by glutamate in the alpha-chain of HbA
4)
A nonsense mutation in the beta-chain of HbA
5)
NULL
Answer :
1
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