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Reported Question / Answer
Q.) A 48 years old woman was admitted with a history of weakness for two months.On examination cervical lymph nodes were found enlarged and spleen was palpable 2 cm below the costal margin.Her hemoglobin was 10.5 g/dl, platelet count 237 x 109/L and total leukocyte count 40 x 109/L, within included 80% mature lymphoid cells with coarse clumped chromatin.Bone marrow revealed a nodular lymphoid infiltrate.The peripheral blood lymphoid cells were positive for CD 19, CD 5, CD 20 and CD 23 and were negative for CD 79 B and FMC - 7 .What is the most likely diagnosis -C
1)
T - cell rich B - cell lymphoma with leukemic spill over the blood
2)
Chronic lymphocytic leukemia
3)
Mantle cell lymphoma
4)
A definite diagnosis can not be made in this patient ithout lymph node biopsy
5)
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