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Reported Question / Answer
Q.) Cardiac or central nervous system toxicity may result when standard lidocaine doses are administered to patients with circulatory failure.This may be due to the following reason:
1)
There is a sudden out-burst of release of adreneline,noradreneline and dopamine in brain and heart
2)
Lidocaine is converted into a toxic metabolite due to its longer stay in liver.
3)
Lidocaine concentration are initially higher in relatively well perfused tissues such as brain and heart
4)
Histamine receptors in brain and heart gets suddenly activated in circulatory failure
5)
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Answer :
3
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