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Reported Question / Answer
Q.) Despite their short half lives(2 hours), Proton pumps Inhibitors(PPIs) cause a prolonged suppression of acid secretion(up to 48 hours) because -
1)
They are prodrugs and undergo activation gradually
2)
They exit from the plasma and enter acid secretory canaliculi and stay here, blocking the secretion of acid for a long time
3)
They irreversibly inhibit the proton pump molecule and hence, acid secretion requires synthesis of new proton pumps
4)
They are avilable as enteric coated capsules, from which drug is gradually released
5)
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3
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