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Reported Question / Answer
Q.) Imipenem,a newer antibiotic with a broad antibacterial spectrum,is coadministered with cilastin because:
1)
The combination of these antibiotics is Synergistic against Pseudomonas species
2)
Cilastin aids the gastrointestinal absorption of the active moiety,imipenem
3)
Cilastin inhibits a Beta-lactamase that destroys imipenem
4)
Cilastin inhibits an enzyme in the kidney that destroys imipenem
5)
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Answer :
4
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