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Reported Question / Answer
Q.) A 4 year old boy was admitted with a history of abdominal pain and fever for two months,maculopapular rash for 10 days, and dry cough, dyspnea and wheezing for 3 days.On examination,liver and spleen were enlarged 4 cm and 3 cm respectively below the costal margin.His hemoglobin was 10.0g/dl,platelet count 37x109/L and total leukocyte count 70x109/L,which included 80% eosinophils.Bone marrow examination revealed a cellular marrow comprising 45% blasts and 34% eosinophils and eosinophilic precursors.The blasts stained negative for myeloperoxidase and non-specific esterase and were positive for CD19,CD10,CD22 and CD20.Which one of the following statements in not true about this disease?
1)
Peripheral blood eosinophilia may normalize with chemotherapy.
2)
Inv (16) is often detected in the blasts and the eosinophils.
3)
Eosinophils are not part of the neoplastic colon.
4)
t(5:14) rearrangement may be detected in blasts.
5)
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Answer :
2
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