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Reported Question / Answer
Q.) The extent to which ionization of a drug takes place is dependent upon pKa of the drug and the pH of the solution in which the drug is dissolved. Which of the following statements is not correct:
1)
Small changes of pH near the pKa of a weak acidic drug will not affect its degree of ionization.
2)
pKa of a drug is the pH at which the drug is 50% ionized
3)
Phenobarbitone with a pKa of 7.2 is largely ionized at acid pH and will be about 40% non-ionized in plasma.
4)
Knowledge of pKa of a drug is useful in predicting its behaviour in various body fluids.
5)
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